EDUCATION
Ph.D. Pharmacology & Toxicology, University of California, Davis.
September 2004 Dissertation: Proteins Targeted by Reactive Metabolites of Naphthalene and 1-Nitronaphthalene in Airways of Mouse and Rhesus Macaque
Advisor: Dr. Alan Buckpitt.
Dissertation Committee: Profs. Charles Plopper and Marion Miller
M.S. Fisheries Science, National Taiwan University, Taiwan. June 1997
Thesis: Isolation and Characterization of (I) Digalactosyldiacylglycerols from Liagora orientalis J. Agardh and L. boergesnii Yamada and (II) Acylphloroglucinols from Zonaria diesingiana J. Ag.
Advisor: Dr. Hong-Nong Chou.
B.S. Marine Resources, National Sun Yat-Sen University, Taiwan. June 1995
RESEARCH SPECIALIZATION
1. Toxicology;
2. Environmental toxicology;
3. Metabolomics;
4. Proteomics;
5. Analytical chemistry.
AWARDED GRANT
“Acute and Chronic Effects of Crude and Dispersed Oil on the Pre-Smolt Stage of Chinook Salmon” funded by California Department of Fish and Game’s Oil Spill Response Trust Fund through the Oiled Wildlife Care Network at UCDavis (2 years, $78,425)
October 2005
AWARDS AND HONORS
Travel Fellowship for oral presentation in 3rd International Proteomics Conference, International Proteomic Conference Committee 2004
Graduate Student Travel Award to 2003 Proteomic Forum in Munich, Germany, UC Davis 2003
Travel Award to 2003 Proteomic Forum in Munich Germany, Taiwan Ministry of Education 2003
Travel Award to Mass Spectrometry Molecular and Cellular Proteomics Conference, Mass Spectrometry Molecular and Cellular Proteomics Conference Committee 2001
NIEHS/UCD Superfund Basic Research and Training Program Fellowship 2001-2003
Fellowships from Taiwan Ministry of Education to study Toxicology in the U.S. 1998-2001
Graduate Student Scholarship, Taiwan Ministry of Education 1995-1997
RESEARCH AND RELATED EXPERIENCE
Post-Doctoral Researcher 2004-present
Department of Environmental Toxicology, University of California, Davis
Supervisor: Dr. Ron Tjeerdema
Graduate Student Researcher 1999-2004
School of Vet. Med.: Molecular Biosciences, University of California, Davis
Advisor: Dr. Alan Buckpitt
Teaching Assistant 2000
Graduate Group of Pharmacology & Toxicology, University of California, Davis
Class: Principles of Pharmacology & Toxicology II
Instructor: Dr. Isaac Pessah
Post Graduate Researcher 1997-1998
Marine Natural Product Chemistry Lab, National Taiwan University
Supervisor: Dr. Hong-Nong Chou
Graduate Research Assistant 1995-1997
Marine Natural Product Chemistry Lab, National Taiwan University
Advisor: Dr. Hong-Nong Chou
PUBLICATIONS
· Lin CY, Wu H, Tjeerdema RS, and Viant MR. Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. Metabolomics, in press.
· Lin CY, Viant MR, and Tjeerdema RS. (2006) Metabolomics: Methodologies and Applications in the Environmental Sciences (review). Journal of Pesticide Science, 31: 245-251.
· Lin CY, Boland BC, Lee YJ, Salemi MR, Morin D, Miller LA, Plopper CG, and Buckpitt AR. (2006) Identification of Proteins Adducted by Reactive Metabolites of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques. Proteomics, 6: 972-982.
· Lin CY, Isbell MA, Morin D, Boland BC, Salemi MR, Jewell WT, Weir AJ, Fanucchi MV, Baker GL, Plopper CG, and Buckpitt AR. (2005) Characterization of a Structurally Intact in situ Lung Model and Comparison of Naphthalene Protein Adducts Generated in this Model vs. Lung Microsomes. Chemical Research in Toxicology, 18: 802 -813.
· Boland B, Lin CY, Morin D, Miller L, Plopper C, and Buckpitt A. (Boland and Lin contributed equally) (2004) Site Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques. Journal of Pharmacology and Experimental Therapeutics, 310: 546-54.
· Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin CY, Taff A, et al. (2002) Naphthalene-Induced Respiratory Tract Toxicity: Metabolic Mechanisms of Toxicity. Drug Metabolism Reviews. 34: 791-820.
· Hsieh F, Wu HD, Lin CY, and Tjeerdema RS. Synthesizing information in nuclear magnetic resonance spectroscopic data: chemical shift based meta-ANOVA analysis. (submitted to Biometrics)
CONFERENCE PRESENTATIONS
· Lin CY, Anderson B, Phillips B, Peng A, Hsieh F, Viant M, and Tjeerdema R. “Toxic Effects of Dispersed and Non-dispersed Oil on Chinook Salmon Smolts (Oncorhynchus tshawytscha) Using Metabolomics” Coastal Response Research Center Workshop “Polycyclic Aromatic Hydrocarbon Toxicity Summit” (invited speaker), Seattle, WA (2006)
· Lin CY, Anderson B, Phillips B, Peng A, Hsieh F, Viant M, and Tjeerdema R. “Metabolic Impacts on Chinook Salmon Smolts Exposed to Crude Oil or Dispersed Oil Using One- and Two-dimensional Nuclear Magnetic Resonance Spectroscopy”. The Second Scientific Meeting of the Metabolomics Society, Boston, MA. (2006)
· Lin CY, Wu H, Tjeerdema RS, and Viant MR. “Evaluation of Metabolite Extraction Strategies from Tissue Samples Using NMR Metabolomics”. The Second Scientific Meeting of the Metabolomics Society, Boston, MA. (2006)
· Lin CY, Viant M, Anderson B, and Tjeerdema R. “Metabolomic Analyses of Chinook Salmon Smolts Exposed to Crude Oil or Dispersed Oil”. Society of Toxicology 45th annual meeting, San Diego, CA. (2006)
· Lin CY, Viant M, Anderson B, and Tjeerdema R. “Acute Effects of Crude Oil and Dispersed Oil on Chinook Salmon Smolts Using NMR-based Metabolomics”. SETAC North America 26th annual meeting, Baltimore, MD. (2005)
· Lin CY, Viant M, Anderson B, and Tjeerdema R. “Evaluation of Tissue Extraction Methods in NMR Based Metabolomics”. The First International Conference of the Metabolomics Society, Tsuruoka City, Japen. (2005)
· Lin CY, Anderson B, Viant M, and Tjeerdema R. “Acute and Chronic Effects of Crude Oil and Dispersed Oil on Chinook Salmon Smolts (Oncorhynchus tshyawytscha)” Coastal Response Research Center meeting, Silver Spring, MD. (2005)
· Lin CY, Boland B, Lee YJ, Salemi MR, Morin D, Miller LA, Plopper CG, and Buckpitt AR. “Proteins Targeted by Reactive Naphthalene and 1-Nitronaphthalene Metabolites in Dissected Airways of Rhesus Macaques in a Model of Allergic Asthma”. 3rd International Proteomics Conference, Taipei, Taiwan. (2004)
· Buckpitt AR, Lin CY, Baldwin RM, Shultz MA, and Plopper CG. “Species Differences in the Metabolism of Naphthalene”. Society for Risk Analysis Annual Meeting, Palm Springs, CA. (2004)
· Buckpitt AR, Wheelock AM, Isbell M, Lin CY, Boland B, Morin D, and Plopper CG. “Gel Based Proteins in Toxicology: Uses and Limitations”. The 39th Western Regional Meeting, American Chemical Society, Sacramento, CA. (2004)
· Lin CY, Boland B, Lee YJ, Salemi M, Plopper CG, and Buckpitt AR. “Identification of Protein Adducts Generated from Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques”. Proteomic Forum 03’, Munich, Germany. (2003)
· Lin CY, Morin D, Karlsson Å, Boland B, Fanucchi M, Baker G, Day K, Plopper CG, and Buckpitt AR. “Protein Adduction in Naphthalene-Induced Lung Injury Using In Situ Airway Incubation”. 11th North American Meeting of International Society to Study Xenobiotics, Orlando, FL. (2002)
· Lin CY, Karlsson Å, Morin D, Fanucchi M, Plopper CG, and Buckpitt AR. “Adducted Proteins Associated with Naphthalene-Induced Lung Toxicity”. 5th International Symposium on Mass Spectrometry in the Health Sciences: Molecular and Cellular Proteomics, San Francisco, CA. (2001)
· Karlsson Å, Tran M, Morin D, Lin CY, Plopper CG, and Buckpitt AR. “A Novel Method for Isolation of Airway Epithelial Cell Proteins in Rat.” 5th International Symposium on Mass Spectrometry in the Health Sciences: Molecular & Cellular Proteomics, San Francisco, CA. (2001)
· Lin CY, Karlsson Å, Morin D, and Buckpitt AR. “Proteomic Detection of Differential Protein Expression Using Fluorescent Dyes”. UCDavis Conference for Environmental Health Scientists, Napa, CA. (2000)
· Lin CY, Morin D, Danham D, Rice B, Hammock B, and Buckpitt AR. “Proteomics in Superfund-Application to Toxicity”. UCDavis Superfund meeting, Davis, CA. (1999)
· Lin CY and Chou HN. “Isolation and Characterization of Digalactosyldiacylglycerols from Liagora orientalis J. Agardh and L. boergesnii Yamada”. Taiwan Aquaculture Annual Symposium, Taiwan. (1997)
· Lin CY and Chou HN. “Isolation and Characterization of Acylphloroglucinols from Zonaria diesingiana J. Ag”. Taiwan Aquaculture Annual Symposium, Taiwan. (1995)