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NIEHS CENTER FOR ENVIRONMENTAL HEALTH
SCIENCES
The NIEHS Center for Environmental Health Sciences (CEHS) at UC Davis funds several pilot projects each year. The Center's mission is to study the health effects of agrochemicals and related xenobiotics, particularly the mechanistic aspects of toxicology.
Letter of Intent: Deadline will be announced soon.
Application Deadline: Will be announced soon.
Eligibility for funding is limited to pilot projects that:
1. Provide initial support for new investigators with P.I. status (who have not received NIH R01, R29, P01 awards) to establish new lines of research.
2. Allow exploration of innovative new research directions (significant departure from ongoing funded research) by CEHS faculty.
3. Stimulate established investigators outside the CEHS to explore innovative new research projects in environmental health, generally in collaboration with CEHS faculty, and who might offer innovative ideas or special skills which benefit this center.
4. Support technical advances to develop a specific technical expertise that the CEHS needs.
A successful application is anticipated to:
Propose research that is relevant to the goals and mission of the Center and is relevant to real world health problems.
Be innovative (including high risk) and provide a new direction or dimension to the repertoire of CEHS research.
Stimulate use of core facilities and collaboration between Center labs and the recipient lab.
Lead to tangible results in a 1-2 year period with a reasonable likelihood of new NIH R01 grant funding.
Lead to continued cooperation with the Center and possible membership (for outside applicants).
The Center anticipates making up to 5 awards of $15,000 to $30,000 each with the possibility of renewal for a second year. Some of the funding may be derived from core utilization. Recipients of awards will provide a year-end progress report documenting collaborations and core use. Renewal for a second year will be by application in competition with new applications and must include a progress report. Recipients will inform the Center of publications and competitive grants received subsequently as a result of the supported research.
Procedure:
Letter of intent: A short (half page) summary giving the title and subject of the proposal must be submitted to the CEHS.
Proposal: Seven (7) hard copies of the application and one emailed copy must be received.
An application must include:
Brief background and statement of hypothesis and significance
Experimental plan, methods and specific collaborations/core use
Anticipated results
Source of potential future independent funding
Explanation of pilot project eligibility (categories 1-4)
Budget with justification for direct costs (personnel, supplies, equipment, but no travel)
The description section (background, hypothesis, methods, results, etc.) of the application should not exceed 6 pages in double-spaced text. In addition, you should attach a list of bibliographic references (no page limit), a budget page, and an NIH 4-page biographical sketch for each investigator.
It is NOT necessary to route this application through your dean's office or the Office of Research.
For questions concerning this program contact: Andrew Porter (530-752-4251, asporter@ucdavis.edu).
Technical inquiries can be answered by Robert Rice (rhrice@ucdavis.edu).
A list of CEHS investigators and their areas of interest may be found at http://www.envtox.ucdavis.edu/cehs/faculty.htm.
Letters of intent and proposals should be sent via email AND hard copy to: Andrew Porter
Department of Environmental Toxicology
4251 Meyer Hall
University of California
One Shields Avenue
Davis, CA 95616 Tel 530-752-4251, Fax 530-752-3394, asporter@ucdavis.edu
LIST OF AWARDED PROJECTS - 1992-2007
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Year 15 (2006-2007)
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Title of Project
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Status
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Martha Stiles
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Public Health Professionals - Survey of Needs
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ongoing
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Radhika Kajekar
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Environmental Tobacco Smoke and Neurodevelopmental outcomes
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ongoing
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Matthew Wood
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Oxidative Stress Perception and Signalling Mechanisms
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ongoing
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Richart Harper
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Duox-2 and host response to rhinovirus
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ongoing
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Nicholas Kenyon
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Effects of L-arginine supplementation in adults with moderate to severe asthma
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ongoing
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Year 14 (2005-2006)
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Title of Project
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Status
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Jiangang Chen
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A Transcriptional Activity Assay to Detect, Identify and Characterize Agriculture-Related Androgenic and Anti-Androgenic Xenobiotics
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1 publication
1 contract - US EPA; “A Transcriptional Activity Assay to Detect Identify and Characterize Agriculture Related Androgenic and Anti-Androgenic Xenobiotics”
01/01/2006-12/31/2006
$65,516
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Cecilia Giulivi
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Toxicology of Dietary Flavonoids on Protein Nitration
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Zelanna Goldberg
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A Proteomic Analysis of Arsenic and Low Dose Ionizing Radiation as Interacting Toxicants in a Human Keratinocyte Model
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1 grant - DAF/AIR Force Misc Bases & Agencies; “Molecular mechanisms of nonlinearity in response to low-dose ionizing radiation”
01/01/06-02/28/07
$150,000
2 Manuscripts in preparation
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William Jewell
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Proteins Adducted by the Rice Herbicide Molinate: Identification and role in Testicular Toxicity
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Marion Miller
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Proteins Adducted by the Rice Herbicide Molinate: Identification and Role in Testicular Toxicology
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Robert Rice
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Gene Knockdown by Retrovirally Delivered siRNA
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Christoph Vogel
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Molecular Aspects of the Development of Leukemia and Non-Hodgkin Lymphoma Induced by Environmental Risk Factors
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2 Grants
1. Cal EPA; $200,000; “Assessment of Health Impacts of Particulate Matter from Indoor Sources”
2. NIOSH; $200,000; “Respiratory Health and Exposures on Large California Dairies”
2 Manuscripts in preparation
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Jooyoung Lee
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The Modulation of Breast Tumor Growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Mediated Through the Expression of Cyclooxygenase-2 in macrophages
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| Year 13 (2004-2005) |
Title |
| Abdul Barakat |
Effect of Ultrafine Particles on Inflammation in Vascular Endothelial Cells |
| Dietmar Kueltz |
Molecular Profiling of Cisplatin and Heavy Metal Nephrotoxicity |
| Patricia Oteiza |
Marginal Zinc Deficiency May Enhance the Susceptibility of Neurons to Lead Toxicity through the Triggering of Oxidant-Sensitive Signaling Cascades |
| Guiseppe Valacchi |
Do Environmental Pollutants Modulate the Development of Atopic Dermatitis? |
| Christopher Vogel |
Molecular Aspects of the Development of Leukemia and Non-Hodgkins Lymphoma Induced by Environmental Riusk Factors |
| Year 12 (2003-2004) |
Title |
| Mark Viant |
Of Mice and Metabolomics--Quantifying Susceptibility to Endocrine Disruption |
| David Furlow |
Development of a Screen for Nuclear Receptor Activation in Live Vertebrate Embryos and Identificatin of an Endogenous RXR Ligand |
| Kiyoung Lee |
Use of An Aerodynamic Model to Characterize Mass Transfer to Passive Samplers for More Accurate Measurement |
| Jason Eiserich |
Endogenous Formation of Halogenated Ah Receptor Agonists by Leukocyte-Derived Heme Peroxidases |
| Christopher Vogel |
Mechanisms of Macrophage Transformation in Foam Cells by Environmental Pollutants like Dioxins, PCBs and Airborne Particles |
| Heidrun Gross |
Neuroprotective Effects of Dietary Flavonoids Against Environmental Exposure to Xenobiotics |
| Year 11 (2002-2003) |
Title |
| Biao Shi and Rivkah Isseroff |
Heat Shock Protein HSP27 Inhibits UVB-Induced Apoptosis in Human Cornal Epithelial Cells |
| Lisa Miller |
The Influence of Airborne Pollutants on Pulmonary Immune Response to Allergens |
| Kiyoung Lee |
Achieving Accurate Measurement with Minimal Face Velocity Effect of Passive Sampler |
| Melanie Greeley |
Can Bone Marrow Mesenchymal Stem Cells Survive, Proliferate and Differentiate in Rat Livers Injured by a Chemical Toxin? |
| Year 10 (2001-2002) |
Title |
| D. A. Thompson, C. Morriseau, B. D. Hammock |
Effect of Ureas and Like Agrochemicals on Gene Induction of Proteins Involved in the Immune Response and Cell Replication |
| Biao Shi and R. Rivkah Isseroff |
UV Exposure and Corneal Damage In Agricultural Workers: A Role for 27 kDA Heat Shock Protein in Protection of Corneal Epithelial Cells from UV Irradiation |
| Alice Wong, Gino Cortopassi |
The Effects of Rotenone on Alpha-Synuclein Expression in a Human Neuronal Cell Line |
| A. E. Mitchell |
Mechanisms of In Vivo Protein Modification to the Cancer Defense Enzymes Glutathione S-Transferase: Biomarkers for Chemical and Oxidative Stress |
| Jimmy Spearow and Dorothy Woolley |
Genetic Variation in Sensitivity to Environmental Toxicants: Effects on Gene Expression |
| L. Lanoue |
Assessing the Leukemogenic Effect of High Intake of Flavonoids During Pregnancy |
| Year 9 (2000-2001) |
Title |
| P. Richard Vulliet/Margaret Yole |
Alteration of T Cell Signaling Produced
by Immunotoxic Agents |
| Enoch Baldwin/Michael Denison |
Probing Structure and Specificity Through
Crystallographic Studies of Ligand Binding to the Aromatic
Hydrocarbon Receptor |
| D. A. Thompson/C. Morisseau/B. D.
Hammock |
Effect of Ureas and Like Agrochemicals
on Gene Induction of Proteins Involved in the Immune
Response |
| Year 8 (1999-2000) |
Title |
| Laura Van Winkle/Alan Buckpitt/Charles
Plopper |
Pulmonary Tolerance In Vitro |
| Jeff Gregg, Robert Rice |
CHIP-Based Expression Analysis of
Arsenate Induced Carcinogenesis |
| Patty Wong-Yim, Isaac Pessah |
Polychlorinated Biphenyls (PCBs) Promote
Cell Cycle Progression in T-Cells by Altering Immunophilin
(FKBP12, FK506 Binding Protein, 12 kDa)-Regulated Pathways |
| Enoch Baldwin, Michael Denison |
Probing Structure and Specificity through
Crystallographic Studies of Ligand Binding to the Aromatic
Hydrocarbon Receptor |
| P. Richard Vulliet, Margaret Yole |
Alteration of T-Cell Signaling by Immunotoxic
Agents |
| Year 1 (1992-1993) 6 mos |
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| Marion Miller |
Testicular toxicity of dinitrobenzene |
| Lynn Wiley |
Does TCDD alter expression of
EGFR MRNA's in the preimplantation mouse embryo? |
| Year 2 (1993-1994) |
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| Marion Miller |
Benomyl-induced testicular toxicity:
role of tubulins |
| Catherine VandeVoort |
Response of mammalian ovarian
follicle-oocyte complex to TCDD |
| Prabhakara Choudary |
Development of antibody technology |
| Isaac Pessah |
Mechanisms by which polychlorinated
hydrocarbons alter calcium channel function and signalling |
| Michael Denison |
Generation and characterization
of putative Ah receptor mutants |
| Year
3 (1994-1995) |
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| Marion Miller |
Testicular toxicity of benomyl |
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| Ellen Gold |
Reproductive health of female
migrant farm workers |
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Grace Rosenquist/
Dorothy Woolley |
Brain CCK expression after lindane
exposure |
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| Bruce Hammock/David Grant |
Effect of agrochemicals on arachidonic
acid metabolism |
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| Jeff Cheek |
Cytotoxicity of ozone and P450-activated
agrochemicals in pulmonary epithelium |
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| Isaac Pessah |
Calcium-mediated mechanisms of
PCB neurotoxicity |
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| Marc Schenker |
Pulmonary fibrosis & mineral
content of lung tissues |
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| Richard Vulliet |
Molecular mechanism of neurotoxic
agrochemicals |
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| Year 4 (1995-1996) |
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| Marion Miller/Trish Berger |
Membrane markers for toxicant-induced
alterations in sperm-egg interactions |
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| David Gilchrist |
Apoptosis-inducing mycotoxins |
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| Year 5 (1996-1997) |
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| David Gilchrist |
Apoptosis-inducing mycotoxins |
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| Alan Conley/Bill Lasley/Essam
Enan |
Pesticide-induced alterations
in estradiol signaling pathways |
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| Kent Pinkerton/Marc Schenker/
Randy Southard/Francis Green |
Pulmonary fibrosis and mineral
content of lung tissues |
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| Year 6 (1997-1998) |
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| Bill Lasley/Daniel Jones/Joseph
Hill |
Periimplantation biomarkers of human spontaneous abortion |
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| Lynn Wiley/James Overstreet/ Barry
Wilson |
Developing a mouse model for studies
on heritable effects of male methamidophos exposure |
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| Richard Vulliet/Dorothy Woolley |
Toxicity of the newer nicotinoid
pesticides in differentiated mammalian neural tissues |
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| Year 7 (1998-1999) |
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Prabhakara Choudary/Marvin
Goodrow/Bill Lasley/Shirley Gee/Alan Buckpitt/George
Bruening
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Recombinant oligopeptides with agrochemical-binding
specificities: Direct selection from phage display
libraries
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| Lynn Wiley/James
Overstreet/ Barry Wilson/Dena Towner/Terrance Hassold |
Developing a mouse model for
studies on heritable effects of male methamidophos exposure |
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| Jiang Zheng/Richard
Perez/Bruce Hammock/Charles Plopper |
Do
pesticides modulate linoleate oxylipid production and
toxicity in Kupffer cells? |
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| Laura Van Winkle/Alan
Buckpitt/Charles Plopper |
Pulmonary Tolerance
in Vitro |
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Pilot Project Returns for the first five years, 1992-1997
Total amount awarded in pilot projects: $354,970
Activities resulting from awards:
Total number of published papers: 21
Total number of accepted abstracts: 7
Total number of manuscripts submitted and in preparation:
17
Total number of grants under review/revision: 9
Funded Grants:
Total $ amount for NIH Grants funded $2,444,313 or given a
fundable priority score
Total $ amount for non-NIH grants funded $778,624 (e.g.,
American Heart Association, various UC programs, Sandia Laboratory,
CA Dept. of Justice, CA Water Resources Board)
In addition to having received a good return on the money
invested in the pilot program, two of the grantees eventually
also were given Center member status. The pilot program thus
has not only expanded research expertise, but is an effective
recruiting tool, capable of attracting new talent and expertise
to the Center.
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