Research
Overall, my research interests lie in the area of how chemical metabolism leads to formation of toxic metabolites. Specifically, I am investigating the role of metabolic activation mechanisms in testicular toxicity. As we learn more about the nature of metabolite(s) responsible for testicular toxicity, the chemical biological interactions which make the testis specifically vulnerable to the effects of toxicants are being investigated. Testicular toxicants which I am currently studying are the nitroaromatic compound, 1,3-dinitrobenzene, the fungicide benomyl and the rice herbicide molinate. Another of my research interests is the development of sperm biomarkers which signal damage to the male reproductive tract. We are using biomarkers which are biophysical (sperm motility and morphology), biochemical (sperm oxidative and sulfhydryl status) and more recently sperm membrane proteins. My areas of expertise are male reproductive toxicology, metabolism and pharmaco/toxicokinetics, liver and testis cell cultures, separation and quantitation techniques for metabolites and biomolecules
Aberdeen University (Scotland) - Pharmacology - 1976 BS
Medical University of South Carolina - Pharmacology - 1982 Ph.D