Molecular toxicology; biochemical and molecular mechanisms of action of halogenated aromatic hydrocarbons and related chemicals; mechanisms of induction of drug metabolizing enzymes; structure and function of receptors for hormones and xenobiotics; gene expression; bioassay systems for detection of environmental contaminants.
Cornell University - Environmental Toxicology - 1984 Ph.D.
Denison, M.S. and Nagy, S.R. (2003) Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals, Ann. Rev. Pharmacol. Toxicol. 43, 309-334.
Denison, M.S., Zhao, B., Baston, D.S., Clark, G.C., Murata, H. and Han, D.-H. (2004) Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals, Talanta 63, 1123-1133.
Klein, G.P., Hodge, E.M., Diamond, M.L., Yip, A. Dann, T., Stern, G., Denison, M.S. and Harper, M.S. (2006) Gas-phase ambient air contaminants exhibit significant dioxin-like and estrogen- like activity in vitro, Environ. Health Perspect. 114, 697-703.
Peters, A.K., Nijmeijer, S., Gradin, K., Backlund, M., Bergman, A., Poellinger, L., Denison, M.S. and Van den Berg, M. (2006) Interactions of polybrominated diphenyl ethers (PBDEs) with the aryl hydrocarbon receptor (AhR) pathway, Toxicol. Sci. 92, 133-142.
Zhao, B., Baston, D.S., Hammock, B.D. and Denison, M.S. (2006) Interaction of diuron and related substituted phenylureas with the Ah receptor pathway, J. Biochem. Molec. Toxicol. 20, 103-113.
Pandini, A., Denison, M.S., Song, Y., Soshilov, A. and Bonati, L. (2007) Structural and functional characterization of the AhR ligand binding domain by homology modeling and mutational analysis, Biochemistry 23, 696-708.