Pilot Projects

NIEHS CENTER FOR ENVIRONMENTAL HEALTH SCIENCES

The NIEHS Center for Environmental Health Sciences (CEHS) at UC Davis funds several pilot projects each year. The Center's mission is to study the health effects of agrochemicals and related xenobiotics, particularly the mechanistic aspects of toxicology. 

Letter of Intent: Deadline will be announced soon.

Application Deadline: Will be announced soon.

Eligibility for funding is limited to pilot projects that:

1. Provide initial support for new investigators with P.I. status (who have not received NIH R01, R29, P01 awards) to establish new lines of research.
2. Allow exploration of innovative new research directions (significant departure from ongoing funded research) by CEHS faculty.
3. Stimulate established investigators outside the CEHS to explore innovative new research projects in environmental health, generally in collaboration with CEHS faculty, and who might offer innovative ideas or special skills which benefit this center.
4. Support technical advances to develop a specific technical expertise that the CEHS needs. 

A successful application is anticipated to:
Propose research that is relevant to the goals and mission of the Center and is relevant to real world health problems.
Be innovative (including high risk) and provide a new direction or dimension to the repertoire of CEHS research.
Stimulate use of core facilities and collaboration between Center labs and the recipient lab.
Lead to tangible results in a 1-2 year period with a reasonable likelihood of new NIH R01 grant funding.
Lead to continued cooperation with the Center and possible membership (for outside applicants).

The Center anticipates making up to 5 awards of $15,000 to $30,000 each with the possibility of renewal for a second year. Some of the funding may be derived from core utilization. Recipients of awards will provide a year-end progress report documenting collaborations and core use. Renewal for a second year will be by application in competition with new applications and must include a progress report. Recipients will inform the Center of publications and competitive grants received subsequently as a result of the supported research.

Procedure:

Letter of intent: A short (half page) summary giving the title and subject of the proposal must be submitted to the CEHS.

Proposal: Seven (7) hard copies of the application and one emailed copy must be received.

An application must include:
Brief background and statement of hypothesis and significance
Experimental plan, methods and specific collaborations/core use
Anticipated results
Source of potential future independent funding
Explanation of pilot project eligibility (categories 1-4)
Budget with justification for direct costs (personnel, supplies, equipment, but no travel)

The description section (background, hypothesis, methods, results, etc.) of the application should not exceed 6 pages in double-spaced text. In addition, you should attach a list of bibliographic references (no page limit), a budget page, and an NIH 4-page biographical sketch for each investigator.

It is NOT necessary to route this application through your dean's office or the Office of Research.

For questions concerning this program contact: Andrew Porter (530-752-4251, asporter@ucdavis.edu).

Technical inquiries can be answered by Robert Rice (rhrice@ucdavis.edu).

A list of CEHS investigators and their areas of interest may be found at http://www.envtox.ucdavis.edu/cehs/faculty.htm.

Letters of intent and proposals should be sent via email AND hard copy to:
Andrew Porter
Department of Environmental Toxicology
4251 Meyer Hall
University of California
One Shields Avenue
Davis, CA 95616
Tel 530-752-4251, Fax 530-752-3394, asporter@ucdavis.edu


LIST OF AWARDED PROJECTS - 1992-2007

Year 15 (2006-2007)

Title of Project

Status

Martha Stiles

Public Health Professionals -                Survey of Needs

ongoing

Radhika Kajekar

Environmental Tobacco Smoke and Neurodevelopmental outcomes

ongoing

Matthew Wood

Oxidative Stress Perception and Signalling Mechanisms

ongoing

Richart Harper

Duox-2 and host response to rhinovirus

ongoing

Nicholas Kenyon

Effects of L-arginine supplementation in adults with moderate to severe asthma

ongoing

 

 

 

Year 14 (2005-2006)

Title of Project

Status

Jiangang Chen

 

A Transcriptional Activity Assay to Detect, Identify and Characterize Agriculture-Related Androgenic and Anti-Androgenic Xenobiotics

1 publication

1 contract - US EPA; “A Transcriptional Activity Assay to Detect Identify and Characterize Agriculture Related Androgenic and Anti-Androgenic Xenobiotics”

01/01/2006-12/31/2006

$65,516

Cecilia Giulivi

 

Toxicology of Dietary Flavonoids on Protein Nitration

 

Zelanna Goldberg

 

A Proteomic Analysis of Arsenic and Low Dose Ionizing Radiation as Interacting Toxicants in a Human Keratinocyte Model

1 grant -  DAF/AIR Force Misc Bases & Agencies; “Molecular mechanisms of nonlinearity in response to low-dose ionizing radiation”

01/01/06-02/28/07

$150,000

2 Manuscripts in preparation

William Jewell

 

Proteins Adducted by the Rice Herbicide Molinate: Identification and role in Testicular Toxicity

 

Marion Miller

Proteins Adducted by the Rice Herbicide Molinate:  Identification and Role in Testicular Toxicology

 

Robert Rice

 

Gene Knockdown by Retrovirally Delivered siRNA

 

Christoph Vogel

 

Molecular Aspects of the Development of Leukemia and Non-Hodgkin Lymphoma Induced by Environmental Risk Factors

2 Grants –

1. Cal EPA; $200,000; “Assessment of Health Impacts of Particulate Matter from Indoor Sources”

2. NIOSH; $200,000; “Respiratory Health and Exposures on Large California Dairies”

2 Manuscripts in preparation

Jooyoung Lee

 

The Modulation of Breast Tumor Growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Mediated Through the Expression of Cyclooxygenase-2 in macrophages

 

 

 

 Year 13 (2004-2005)  Title
Abdul Barakat  Effect of Ultrafine Particles on Inflammation in Vascular Endothelial Cells
Dietmar Kueltz Molecular Profiling of Cisplatin and Heavy Metal Nephrotoxicity
Patricia Oteiza Marginal Zinc Deficiency May Enhance the Susceptibility of Neurons to Lead Toxicity through the Triggering of Oxidant-Sensitive Signaling Cascades
Guiseppe Valacchi Do Environmental Pollutants Modulate the Development of Atopic Dermatitis?
Christopher Vogel Molecular Aspects of the Development of Leukemia and Non-Hodgkins Lymphoma Induced by Environmental Riusk Factors
 Year 12 (2003-2004)  Title
Mark Viant  Of Mice and Metabolomics--Quantifying Susceptibility to Endocrine Disruption
David Furlow Development of a Screen for Nuclear Receptor Activation in Live Vertebrate Embryos and Identificatin of an Endogenous RXR Ligand
Kiyoung Lee  Use of An Aerodynamic Model to Characterize Mass Transfer to Passive Samplers for More Accurate Measurement
Jason Eiserich  Endogenous Formation of Halogenated Ah Receptor Agonists by Leukocyte-Derived Heme Peroxidases
Christopher Vogel Mechanisms of Macrophage Transformation in Foam Cells by Environmental Pollutants like Dioxins, PCBs and Airborne Particles
 Heidrun Gross  Neuroprotective Effects of Dietary Flavonoids Against Environmental Exposure to Xenobiotics
 Year 11 (2002-2003)  Title
 Biao Shi and Rivkah Isseroff  Heat Shock Protein HSP27 Inhibits UVB-Induced Apoptosis in Human Cornal Epithelial Cells
 Lisa Miller  The Influence of Airborne Pollutants on Pulmonary Immune Response to Allergens
 Kiyoung Lee  Achieving Accurate Measurement with Minimal Face Velocity Effect of Passive Sampler
 Melanie Greeley  Can Bone Marrow Mesenchymal Stem Cells Survive, Proliferate and Differentiate in Rat Livers Injured by a Chemical Toxin?
 Year 10 (2001-2002)  Title
  D. A. Thompson, C. Morriseau, B. D. Hammock Effect of Ureas and Like Agrochemicals on Gene Induction of Proteins Involved in the Immune Response and Cell Replication
 Biao Shi and R. Rivkah Isseroff UV Exposure and Corneal Damage In Agricultural Workers: A Role for 27 kDA Heat Shock Protein in Protection of Corneal Epithelial Cells from UV Irradiation
 Alice Wong, Gino Cortopassi The Effects of Rotenone on Alpha-Synuclein Expression in a Human Neuronal Cell Line
 A. E. Mitchell Mechanisms of In Vivo Protein Modification to the Cancer Defense Enzymes Glutathione S-Transferase: Biomarkers for Chemical and Oxidative Stress
 Jimmy Spearow and Dorothy Woolley Genetic Variation in Sensitivity to Environmental Toxicants: Effects on Gene Expression
 L. Lanoue  Assessing the Leukemogenic Effect of High Intake of Flavonoids During Pregnancy
 Year 9 (2000-2001)  Title
 P. Richard Vulliet/Margaret Yole  Alteration of T Cell Signaling Produced by Immunotoxic Agents
 Enoch Baldwin/Michael Denison Probing Structure and Specificity Through Crystallographic Studies of Ligand Binding to the Aromatic Hydrocarbon Receptor
 D. A. Thompson/C. Morisseau/B. D. Hammock  Effect of Ureas and Like Agrochemicals on Gene Induction of Proteins Involved in the Immune Response
 Year 8 (1999-2000)  Title
 Laura Van Winkle/Alan Buckpitt/Charles Plopper  Pulmonary Tolerance In Vitro
 Jeff Gregg, Robert Rice  CHIP-Based Expression Analysis of Arsenate Induced Carcinogenesis
 Patty Wong-Yim, Isaac Pessah Polychlorinated Biphenyls (PCBs) Promote Cell Cycle Progression in T-Cells by Altering Immunophilin (FKBP12, FK506 Binding Protein, 12 kDa)-Regulated Pathways
 Enoch Baldwin, Michael Denison Probing Structure and Specificity through Crystallographic Studies of Ligand Binding to the Aromatic Hydrocarbon Receptor
 P. Richard Vulliet, Margaret Yole Alteration of T-Cell Signaling by Immunotoxic Agents
Year 1 (1992-1993) 6 mos
Marion Miller Testicular toxicity of dinitrobenzene
Lynn Wiley Does TCDD alter expression of EGFR MRNA's in the preimplantation mouse embryo?
Year 2 (1993-1994)
Marion Miller Benomyl-induced testicular toxicity: role of tubulins
Catherine VandeVoort Response of mammalian ovarian follicle-oocyte complex to TCDD
Prabhakara Choudary Development of antibody technology
Isaac Pessah Mechanisms by which polychlorinated hydrocarbons alter calcium channel function and signalling
Michael Denison Generation and characterization of putative Ah receptor mutants


Year 3 (1994-1995)
Marion Miller Testicular toxicity of benomyl
Ellen Gold Reproductive health of female migrant farm workers
Grace Rosenquist/
Dorothy Woolley
Brain CCK expression after lindane exposure
Bruce Hammock/David Grant Effect of agrochemicals on arachidonic acid metabolism
Jeff Cheek Cytotoxicity of ozone and P450-activated agrochemicals in pulmonary epithelium
Isaac Pessah Calcium-mediated mechanisms of PCB neurotoxicity
Marc Schenker Pulmonary fibrosis & mineral content of lung tissues
Richard Vulliet Molecular mechanism of neurotoxic agrochemicals
Year 4 (1995-1996)
Marion Miller/Trish Berger Membrane markers for toxicant-induced alterations in sperm-egg interactions
David Gilchrist Apoptosis-inducing mycotoxins
Year 5 (1996-1997)
David Gilchrist Apoptosis-inducing mycotoxins
Alan Conley/Bill Lasley/Essam Enan Pesticide-induced alterations in estradiol signaling pathways
Kent Pinkerton/Marc Schenker/ Randy Southard/Francis Green Pulmonary fibrosis and mineral content of lung tissues
Year 6 (1997-1998)
Bill Lasley/Daniel Jones/Joseph Hill Periimplantation biomarkers of human spontaneous abortion
Lynn Wiley/James Overstreet/ Barry Wilson Developing a mouse model for studies on heritable effects of male methamidophos exposure
Richard Vulliet/Dorothy Woolley Toxicity of the newer nicotinoid pesticides in differentiated mammalian neural tissues
Year 7 (1998-1999)

 Prabhakara Choudary/Marvin Goodrow/Bill Lasley/Shirley Gee/Alan Buckpitt/George Bruening

 Recombinant oligopeptides with agrochemical-binding specificities: Direct selection from phage display libraries

Lynn Wiley/James Overstreet/ Barry Wilson/Dena Towner/Terrance Hassold Developing a mouse model for studies on heritable effects of male methamidophos exposure  
Jiang Zheng/Richard Perez/Bruce Hammock/Charles Plopper Do pesticides modulate linoleate oxylipid production and toxicity in Kupffer cells?
Laura Van Winkle/Alan Buckpitt/Charles Plopper Pulmonary Tolerance in Vitro





Pilot Project Returns for the first five years, 1992-1997

Total amount awarded in pilot projects: $354,970

Activities resulting from awards:

Total number of published papers: 21

Total number of accepted abstracts: 7

Total number of manuscripts submitted and in preparation: 17

Total number of grants under review/revision: 9


 
Funded Grants:

Total $ amount for NIH Grants funded $2,444,313 or given a fundable priority score

 
Total $ amount for non-NIH grants funded $778,624 (e.g., American Heart Association, various UC programs, Sandia Laboratory, CA Dept. of Justice, CA Water Resources Board)

In addition to having received a good return on the money invested in the pilot program, two of the grantees eventually also were given Center member status. The pilot program thus has not only expanded research expertise, but is an effective recruiting tool, capable of attracting new talent and expertise to the Center.


 

Send Webmaster comments to rlmorrison@ucdavis.edu
URL: http://www.envtox.ucdavis.edu/cehs

Updated 4/10/07